The Endocannabinoid System

Dr. David Allen
a retired Heart Surgeon Explains the importance of The Endocannabinoid System

Dr. Bob Melamede & Dr. Julie Holland
Explain The Endocannabinoid System

"Everything in our body is homeostatically regulated by our Endocannabinoid System.. and yet its not taught in medical school?? There is something a little flawed here..."

- Dr. Bob Melamede

Gary Wenk - Professor of Pyschology/Neuroscience The Ohio State University
Explains how cannabis is the only compound known to reduce inflammation in an aging brain. Which is in the background of many age related illness'

VIDEO: Debbie Willison suffered a brain injury 25 years ago. In the last few years she has regained her mentail and physical abilities from the use of cannabis

Dr. Christina Sanchez
Explains the anti-tumor effects of cannabis...

Clinical Endocannabinoid Deficiency in PTSD

Dr. William Courtney
Confirms cannabis oil cures brain tumor in 8 month old

Dr. Hicks
describes the many conditions his patients are using CBD oil for...

Evidence Showing That Cannabis Could Be The Most Nutritional Vegetable In The World
View description of video on youtube for source links

Cannabinoids as antioxidants and neuroprotectants (U.S Government owned patent)

[1 of 5] Mary Lynn Mathre, RN, MSN CARN -
Mary is a Registered Nurse, holds a Master of Science in Nursing and is a Certified Addictions Registered Nurse

  • Topics Dicussed:
  • Tallking to your Doctor about The Endocannabinoid System
  • Understanding ECS
  • Why veterans choose cannabis
  • and much more..

[2 of 5]

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[5 of 5]

Dr Bradstreet - Understanding the Endocannabinoid System in Autism
He also discusses how he only just became aware of The Endocannabinoid System, and that 20 of his colleagues hadn't heard of it either. He also explains a number of interestinglo aspects of ECS.

Dr Michael Geci
Discussing The Endocannabinoid System and how it works on so many different conditions.

Dr. Melamede
How cannabis becomes an essential nutrient and how it is essential for many age related and cognitive issues associated with age.

Dr. Bob Melamede
Explains how EVERYTHING in our Body is regulated by The Endocannabinoid System.

[Part 1] Dr. William Courtney
Discussing the dietary benefits of raw cannabis.

[Part 2] Dr. William Courtney

Lanny Swerdlow
explains the negative effects of alcohol in comparison to cannabis, based on his years of experience as a nurse.

Dr. Melamede
Discussing Bird Flu, Swine, and Flu, and how cannabis may be beneficial in certain circumstances.

Cannabinoids Kills Cancer

(without killing healthy cells)

"Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. "

-National Cancer Institute


Cannabinoids as antioxidants and neuroprotectants (U.S Government owned patent)

Phytocannabinoids in the treatment of cancer (US Patent)

Methods and compositions for treating cancer (US Pantent)

Cancer Research on Google Drive

Cannabis Safety Profile

"In strict medical terms marijuana is far safer than many food we commonly consume. For example, eating ten raw potatoes can result in a toxic response. By comparison, it is physically impossible to eat enough marijuana to induce death."

- DEA Finding of Facts Cannabis Saftey Profile (pg. 56-60)

THC vs Anandamide

(Anandamide is a cannabinoid produced by the body on demand)

"Both THC and anandamide can increase serum levels of ACTH and corticosterone in animals. Those hormones are involved in regulating many responses in the body, including those to inflammation. The possible link between experimental cannabinoid-induced analgesia and reported antiinflammatory effects of cannabinoids is important for potential therapeutic uses of cannabinoid drugs"

- National Academy of Sciences - "Marijuana AND Medicine"
(pg 68)


Recent News & Other Sources:

The Washington Post: No, marijuana use doesn’t lower your IQ

Inergetics' Scientific/Medical Advisory Board to Meet as Company Enters Final Development Phase of New CBD Product Line

CNN Money: Therapix Biosciences Signs Non-Binding Agreement to Acquire Dekel Pharmaceuticals Ltd.

The Washington Post : After California decriminalized marijuana, teen arrest, overdose and dropout rates fell

166,000 Patent results when searching for "Cannabinoid"

20,700 Patent results when searching for "Endocannabinoid"

51,000 Patent results when searching for "Cannabinoid Receptors"

Cannabinoid Patents on Google Drive

CNN: Weed 1 - Dr. Sanjay Gupta Reporting

CNN: Weed 2 - Dr. Sanjay Gupta Reporting

2 senators push for legalization of cannabinoid oil for medical use

Zynerba Pharmaceuticals Raises $13 Million to Develop First and Only Transdermal Cannabinoid Therapies

For physicians, marijuana is a touchy subject

Cannabics Pharmaceuticals Receives Cannabinoid R&D Lab Certification in Israel

New way to boost potency of natural pain relief chemical in body

Research written by Doctors & Scientists on The Endocannabinoid System

Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists at the University of South Florida shows.

At least 16 other National Institutes of Health (NIH) and ceters support research on or related to epilepsies [endocannabinoid-based therapies]

"Studies have revealed that the endocannabinoid system is involved in almost all major immune events."

Care and feeding of the endocannabinoid system

Marijuana Protective in Strokes

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Survey of the Endocannabinoid System in Medical Schools

Introduction to the Endocannabinoid System

Research Papers on ECS

Gene/Protein/Receptor Databases:

Cannabinoid Receptor Type 1 (CB1 aka CNR1)
(Radboud University G Protein-coupled receptors Database)

Cannabinoid Receptor Type 2 (CB1 aka CNR2)
(Radboud University G Protein-coupled receptors Database)

CB1/CNR1 - HUGO Gene Nomenclature Committee

CB2/CNR2 - HUGO Gene Nomenclature Committee

Cannabinoid Receptor 1
(UniProt database funded by National Institutes of Health)

Cannabinoid Receptor 2
(UniProt database funded by National Institutes of Health)

[Genecards database search] Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science
Email questions, comments, or corrections to: If anyone would like to leave an anonymous message about their experience with cannabis, question, or comment please feel free to do so by leaving a voice mail at (619) 928-2392

More Abstracts from Research

1st Department of Internal Medicine Clinic, AHEPA University Hospital, Aristotle University

The endocannabinoid system (ECS) is a lipid signalling system, comprising of the endogenous cannabis-like ligands (endocannabinoids) anandamide (AEA) and 2-arachidonoylglycerol (2-AG), which derive from arachidonic acid. These bind to a family of G-protein-coupled receptors, called CB1 and CB2. The cannabinoid receptor 1 (CB1R) is distributed in brain areas associated with motor control, emotional responses, motivated behaviour and energy homeostasis. In the periphery, the same receptor is expressed in the adipose tissue, pancreas, liver, GI tract, skeletal muscles, heart and the reproduction system. The CB2R is mainly expressed in the immune system regulating its functions. Endocannabinoids are synthesized and released upon demand in a receptor-dependent way. They act as retrograde signalling messengers in GABAergic and glutamatergic synapses and as modulators of postsynaptic transmission interacting with other neurotransmitters. Endocannabinoids are transported into cells by a specific uptake system and degraded by the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). The ECS is involved in various pathophysiological conditions in central and peripheral tissues. It is implicated in the hormonal regulation of food intake, cardiovascular, gastrointestinal, immune, behavioral, antiproliferative and mammalian reproduction functions. Recent advances have correlated the ECS with drug addiction and alcoholism. The growing number of preclinical and clinical data on ECS modulators is bound to result in novel therapeutic approaches for a number of diseases currently treated inadequately. The ECS dysregulation has been correlated to obesity and metabolic syndrome pathogenesis.